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Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure
Sponsor: Hari Narayan
Summary
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.
Official title: CATCH-HF: Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure
Key Details
Gender
All
Age Range
13 Years - 39 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2019-09-30
Completion Date
2030-09-30
Last Updated
2025-01-28
Healthy Volunteers
No
Interventions
Cardiac magnetic resonance imaging (MRI)
Cardiac magnetic resonance imaging will be performed to evaluate cardiac remodeling, function, and tissue characteristics
Accelerometer physical activity monitoring
Measurement of physical activity using hip-worn accelerometer.
Locations (1)
Rady Children's Hospital
San Diego, California, United States