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Study to Evaluate Monotherapy and Combination Immunotherapies in Participants With PD-L1 Positive Non-small Cell Lung Cancer
Sponsor: Arcus Biosciences, Inc.
Summary
This randomized phase 2 open-label study will evaluate the safety and efficacy of zimberelimab (AB122) monotherapy, domvanalimab (AB154) in combination with zimberelimab, and domvanalimab in combination with zimberelimab and etrumadenant (AB928) in front-line, PD-L1 positive, metastatic non-small cell lung cancer.
Official title: A Phase 2 Study to Evaluate the Safety and Efficacy of AB122 Monotherapy, AB154 in Combination With AB122, and AB154 in Combination With AB122 and AB928 in Front-Line, Non-Small Cell Lung Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
151
Start Date
2020-05-28
Completion Date
2025-07-09
Last Updated
2026-06-15
Healthy Volunteers
No
Conditions
Interventions
Domvanalimab
Domvanalimab is a humanized monoclonal antibody targeting human TIGIT
Etrumadenant
Etrumadenant is an A2aR and A2bR antagonist
Zimberelimab
Zimberelimab is a fully human anti-PD-1 monoclonal antibody
Locations (44)
University of Alabama at Birmingham
Birmingham, Alabama, United States
Innovative Clinical Research Institute (ICRI)
Whittier, California, United States
Florida Cancer Specialists
Englewood, Florida, United States
Florida Cancer Specialists
Gainesville, Florida, United States
Florida Cancer Specialists - Panhandle
Tallahassee, Florida, United States
Florida Cancer Specialists - East
West Palm Beach, Florida, United States
Baptist Health Lexington
Lexington, Kentucky, United States
Norton Cancer Institute
Louisville, Kentucky, United States
Ochsner Clinic Foundation
New Orleans, Louisiana, United States
The Valley Hospital - Valley Health System - The Robert and Audrey Luckow Pavilion
Ridgewood, New Jersey, United States
Clinical Research Alliance
Lake Success, New York, United States
Northwell Health Cancer Institute
Lake Success, New York, United States
Wake Forest Baptist Health
Winston-Salem, North Carolina, United States
Allegheny General Hospital (AGH)-Alleghney Singer Research Institute
Pittsburgh, Pennsylvania, United States
Sarah Cannon Research Institute
Nashville, Tennessee, United States
The Center For Cancer And Blood Disorders (Texas Cancer Care)
Fort Worth, Texas, United States
Millennium Oncology
Houston, Texas, United States
Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Blacksburg, Virginia, United States
Virginia Cancer Specialists
Fairfax, Virginia, United States
Border Medical Oncology
Albury, Australia
Coffs Harbour Health Campus
Coffs Harbour, Australia
Adelaide Cancer Centre
Elizabeth Vale, Australia
Shoalhaven Cancer Care Centre
Nowra, Australia
McGill University Health Centre (MUHC) - The Montreal Children's Hospital (MCH)
Montreal, Canada
Hong Kong United Oncology Centre
Hong Kong, Hong Kong
Queen Elizabeth Hospital (Hong Kong)
Hong Kong, Hong Kong
Curie Oncology
Singapore, Singapore
Kosin University Gospel Hospital
Busan, South Korea
Chungbuk National University Hospital (CBNUH)
Cheongju-si, South Korea
Chonnam University Hospital
Hwasun, South Korea
Gachon University Gil Medical Center
Incheon, South Korea
Chonbuk National University Hospital
Jeonju, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Asan Medical Center
Seoul, South Korea
Kangbuk Samsung Hospital
Seoul, South Korea
Korea University Anam Hospital
Seoul, South Korea
St Vincent Hospital of the Catholic University of Korea
Suwon, South Korea
Catholic University of Korea, Uijeongbu St. Mary's Hospital
Uijeongbu-si, South Korea
Taipei Medical University - Shuang Ho Hospital
New Taipei City, Taiwan
Chi Mei Hospital
Tainan, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Medical University Hospital
Taipei, Taiwan
Chang Gung Memorial Hospital at Linkou
Taoyuan, Taiwan