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French COVID Cohort
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Summary
Infectious disease is the single biggest cause of death worldwide. New infectious agents, such as the SARS, MERS and other novel coronavirus, novel influenza viruses, viruses causing viral haemorrhagic fever (e.g. Ebola), and viruses that affect the central nervous system (CNS) such as TBEV \& Nipah require investigation to understand pathogen biology and pathogenesis in the host. Even for known infections, resistance to antimicrobial therapies is widespread, and treatments to control potentially deleterious host responses are lacking. In order to develop a mechanistic understanding of disease processes, such that risk factors for severe illness can be identified and treatments can be developed, it is necessary to understand pathogen characteristics associated with virulence, the replication dynamics and in-host evolution of the pathogen, the dynamics of the host response, the pharmacology of antimicrobial or host-directed therapies, the transmission dynamics, and factors underlying individual susceptibility. The work proposed here may require sampling that will not immediately benefit the participants. It may also require analysis of the host genome, which may reveal other information about disease susceptibility or other aspects of health status.
Official title: Clinical Characterisation Protocol for Severe Emerging Infections
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
4415
Start Date
2020-02-08
Completion Date
2025-08-07
Last Updated
2024-07-30
Healthy Volunteers
No
Conditions
Locations (98)
CHG Agen
Agen, France
Centre Hospitalier Du Pays D'aix
Aix-en-Provence, France
CHU Amiens
Amiens, France
CHU Angers
Angers, France
CH Annecy Genevois
Annecy, France
Hopital privé d'Antony
Antony, France
Hôpital de Mercy. CHR METZ-THIONVILLE
Ars-Laquenexy, France
Centre Hospitalier Henri Duffaut
Avignon, France
Chu Jean Minjoz
Besançon, France
Centre hospitalier de Béziers
Béziers, France
Hôpital Avicenne AP-HP
Bobigny, France
CHU Pellegrin
Bordeaux, France
CHU Ambroise Paré
Boulogne-Billancourt, France
Ch Fleyriat
Bourg-en-Bresse, France
Centre Hospitalier Pierre Oudot
Bourgoin, France
Chru Hopital Cavale Blanche
Brest, France
CHU Brest
Brest, France
Hospices civils de Lyon
Bron, France
CH Cahors
Cahors, France
Centre Hospitalier J.E Techer
Calais, France
Centre Hospitalier Andrée Rosemon
Cayenne, France
Chms Chambery Nh
Chambéry, France
Centre Hospitalier De Cholet
Cholet, France
CHU Gabriel Montpied
Clermont-Ferrand, France
CH Colmar - Hopital Pasteur
Colmar, France
Hôpital Louis Mourier
Colombes, France
Centre hospitalier Alpes Leman
Contamine-sur-Arve, France
Centre hospitalier Intercommunal de Créteil
Créteil, France
Hôpital Henri Mondor
Créteil, France
Centre Hospitalier Dax
Dax, France
CHU Dijon Bourgogne
Dijon, France
CH Annecy Genevois
Épagny, France
CHU de Martinique
Fort de France, France
Hopital Raymond Poincare
Garches, France
CHU Grenoble
Grenoble, France
Grand Hopital de l'Est Francilien site Marne-la-Vallée
Jossigny, France
Chd Les Oudairies
La Roche-sur-Yon, France
Hôpital Universitaire Bicêtre
Le Kremlin-Bicêtre, France
CH du Mans
Le Mans, France
Centre Hospitalier Emile Roux
Le Puy-en-Velay, France
Centre Hospitalier Universitaire de Lille
Lille, France
CHRU Lille, Hôpital Salengro
Lille, France
CHU de Lille
Lille, France
Hôpital de la Croix-Rousse
Lyon, France
Hôpital Louis Raffalli
Manosque, France
Assistance publique hopitaux de Marseille, hopital Nord
Marseille, France
Hopital Européen
Marseille, France
Hôpital Conception
Marseille, France
Groupe Hospitalier Sud Ile De France
Melun, France
CH de Mont Marsan
Mont-de-Marsan, France
Groupe hospitalier du Havre
Montivilliers, France
CHU Montpellier
Montpellier, France
CHU Nantes
Nantes, France
Hopital Américain de Paris
Neuilly-sur-Seine, France
CHU de Nice
Nice, France
CHU Caremeau
Nîmes, France
APHP Bichat
Paris, France
APHP Tenon
Paris, France
CH Lariboisière
Paris, France
Groupe Hospitalier Diaconesses Croix Saint-Simon
Paris, France
Hopital Cochin-CIC1417
Paris, France
Hopital Européen Georges Pompidou
Paris, France
Hopital Saint Antoine
Paris, France
Hopital Saint Louis
Paris, France
La pitié salpetrière
Paris, France
Centre Hospitalier de Pau
Pau, France
CH de Perpignan
Perpignan, France
Centre Hospitalier de Périgueux
Périgueux, France
Hopital Lyon Sud-HCL
Pierre-Bénite, France
CHU de Pointe à Pitre
Pointe à Pitre, France
CHU de Poitiers
Poitiers, France
Ch Cornouaille
Quimper, France
Chu Reims
Reims, France
CHU Rennes Hopital Sud
Rennes, France
Hôpital Pontchaillou
Rennes, France
CHU Charles Nicole
Rouen, France
CHU Rouen Normandie
Rouen, France
CHU Réunion-Felix Guyon
Saint-Denis, France
CHU de Saint-Etienne
Saint-Etienne, France
Hopital d'instruction des armées Begin 69
Saint-Mandé, France
Centre hospitalier Louis Constant Fleming
Saint-Martin, France
Groupe Hospitalier Sud Réunion
Saint-Pierre, France
CH de Saintonge
Saintes, France
Centre Hospitalier de Soissons
Soissons, France
N.H.C. - Nouvel Hopital Civil
Strasbourg, France
Hopital Foch
Suresnes, France
CHR Metz-Thionville -Hopital Bel Air
Thionville, France
Hopitaux du Leman
Thonon-les-Bains, France
Centre Hospitalier Universitaire de Rangueil
Toulouse, France
CHU de Toulouse
Toulouse, France
CHU Toulouse IUCT Institut Universitaire de Cancer de Toulouse
Toulouse, France
CHU Toulouse Larrey
Toulouse, France
Hôpital Gustave Dron
Tourcoing, France
Centre Hospitalier Régional Universitaire de Tours
Tours, France
CHRU de Tours
Tours, France
CHU Nancy
Vandœuvre-lès-Nancy, France
Centre Hospitalier Bretagne Atlantique
Vannes, France
Centre Hospitalier Intercommunal
Villeneuve-Saint-Georges, France