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Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre
Sponsor: University Hospital, Bordeaux
Summary
Systemic sclerosis (SSc) is a rare form of connective tissue disease characterized by vascular involvement and the intensity of fibrosis. The lack of available treatment is largely due to the very fragmented understanding of the pathophysiology of SSc. However, one of the keys to conducting quality research on this disease remains the development of well-documented patient cohorts with reliable biological samples. The main objective of this cohort is to study the natural progression of SSc in a cohort of patients followed over 5 years.
Official title: Cohort of Patients With Systemic Sclerosis and Associated Biological Collection Within the Framework of the RESO Reference Centre for Rare Systemic Autoimmune Diseases
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2020-06-08
Completion Date
2034-06
Last Updated
2025-09-04
Healthy Volunteers
No
Conditions
Interventions
Blood samples
62 ml whole blood for Peripheral blood mononuclear cell (PBMC) and monocytes isolation
Biopsy
Skin biopsies only for volunteers among patients
Bronchoalveolar samples
50 ml of bronchoalveolar samples if pulmonary flare requires this type of exploration only for volunteers among patients
Biopsy
Digestives biopsies if requires this type of exploration in the standard of care only for volunteers among patients
Locations (1)
CHU de Bordeaux - service de rhumatologie
Bordeaux, France