Clinical Research Directory

Inclusion Criteria: * Infants and young children aged from 0 up to and including 10 years of age. * Severe impairment of at least 1 organ system * Impairment of the gastrointestinal tract, i.e. gastrointestinal disease, congenital abnormality, surgical resection, or gastrointestinal dysfunction (including symptoms of gastrointestinal dysmotility or malabsorption). * Receiving at least 75% of their energy intake from Neocate (Neocate Infant or Junior powdered (marketed) product) at the time of study entry (V1). * Expected to receive at least 75% of their energy intake from the study product for at least 4 weeks from study entry (V1). * Written informed consent provided by parents/guardians and assent by the child, if applicable, according to local law. Exclusion Criteria: * Infants born with a gestational age \<37 weeks that are \<40 weeks corrected age at the time of study entry (V1). * Infants or children with endoscopically confirmed eosinophilic oesophagitis and prescribed an amino acid-based formula only for the management of the eosinophilic oesophagitis. * Infants or children with a medical diagnosis that includes only (suspected) cow's milk allergy and/or multiple food allergy. * Infants or children with renal dysfunction, e.g. acute or chronic kidney failure or kidney cancer. * Infants or children with thyroid disorder or parathyroid disorder. * Expected to receive parenteral nutrition during intervention from study entry (V1). * Participation in any other studies involving investigational or marketed products concomitantly or within 1 month prior to study entry (V1). * Investigator's uncertainty about the willingness or ability of the parents/guardians to comply with the protocol requirements.