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Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
Sponsor: AstraZeneca
Summary
A study to assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.
Official title: A Randomised, Multicentre, Double-blind, Placebo-controlled, Phase III Study of First-line Carboplatin and Paclitaxel in Combination With Durvalumab, Followed by Maintenance Durvalumab With or Without Olaparib in Patients With Newly Diagnosed Advanced or Recurrent Endometrial Cancer (DUO-E)
Key Details
Gender
FEMALE
Age Range
18 Years - 150 Years
Study Type
INTERVENTIONAL
Enrollment
805
Start Date
2020-05-05
Completion Date
2027-04-01
Last Updated
2025-12-23
Healthy Volunteers
No
Conditions
Interventions
olaparib
Olaparib tablets
durvalumab
Durvalumab by intravenous infusion
durvalumab placebo
Matching placebo for intravenous infusion
olaparib placebo
Placebo tablets to match olaparib
Carboplatin
Standard of care chemotherapy
Paclitaxel
Standard of care chemotherapy
Locations (202)
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Tucson, Arizona, United States
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Concord, California, United States
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La Jolla, California, United States
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San Francisco, California, United States
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Santa Barbara, California, United States
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Aurora, Colorado, United States
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Fort Lauderdale, Florida, United States
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Tampa, Florida, United States
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Savannah, Georgia, United States
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Honolulu, Hawaii, United States
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Arlington Heights, Illinois, United States
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Chicago, Illinois, United States
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Indianapolis, Indiana, United States
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Louisville, Kentucky, United States
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Baton Rouge, Louisiana, United States
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Boston, Massachusetts, United States
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Saint Paul, Minnesota, United States
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Jackson, Mississippi, United States
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Lebanon, New Hampshire, United States
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Camden, New Jersey, United States
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Paramus, New Jersey, United States
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New York, New York, United States
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New York, New York, United States
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Pinehurst, North Carolina, United States
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Cleveland, Ohio, United States
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Cleveland, Ohio, United States
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Dayton, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Tulsa, Oklahoma, United States
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Eugene, Oregon, United States
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Tigard, Oregon, United States
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Pittsburgh, Pennsylvania, United States
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Providence, Rhode Island, United States
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Sioux Falls, South Dakota, United States
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Chattanooga, Tennessee, United States
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Germantown, Tennessee, United States
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Knoxville, Tennessee, United States
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Bedford, Texas, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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San Antonio, Texas, United States
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Sugar Land, Texas, United States
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Tyler, Texas, United States
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Webster, Texas, United States
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Fairfax, Virginia, United States
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Norfolk, Virginia, United States
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Seattle, Washington, United States
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Morgantown, West Virginia, United States
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Madison, Wisconsin, United States
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Milwaukee, Wisconsin, United States
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Clayton, Australia
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Malvern, Australia
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Melbourne, Australia
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Nedlands, Australia
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Sydney, Australia
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Bruges, Belgium
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Brussels, Belgium
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Charleroi, Belgium
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Ghent, Belgium
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Hasselt, Belgium
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Kortrijk, Belgium
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Leuven, Belgium
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Libramont-Chevigny, Belgium
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Liège, Belgium
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Belo Horizonte, Brazil
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Belo Horizonte, Brazil
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Curitiba, Brazil
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Passo Fundo, Brazil
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Pelotas, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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São José do Rio Preto, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Calgary, Alberta, Canada
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Toronto, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Beijing, China
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Beijing, China
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Changchun, China
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Changchun, China
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Changsha, China
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Changsha, China
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Chengdu, China
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Chongqing, China
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Chongqing, China
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Dalian, China
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Dalian, China
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Guangdong, China
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Guangzhou, China
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Haikou, China
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Harbin, China
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Hefei, China
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Nanning, China
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Shanghai, China
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Shenyang, China
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Taiyuan, China
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Tianjin, China
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Wuhan, China
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Wuhan, China
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Zhanjiang, China
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Zhengzhou, China
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Zhengzhou, China
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Barranquilla, Colombia
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Bogotá, Colombia
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Bogotá, Colombia
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Bogotá, Colombia
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Cali, Colombia
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Medellín, Colombia
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Medellín, Colombia
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Montería, Colombia
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Pereira, Colombia
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Tallinn, Estonia
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Tartu, Estonia
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Bonn, Germany
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Chemnitz, Germany
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Dresden, Germany
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Erlangen, Germany
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Leipzig, Germany
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Athens, Greece
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Chaïdári, Greece
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Thessaloniki, Greece
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Hong Kong, Hong Kong
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Debrecen, Hungary
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Győr, Hungary
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Szolnok, Hungary
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Hisar, India
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Mumbai, India
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Be’er Ya‘aqov, Israel
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Hadera, Israel
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Jerusalem, Israel
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Nahariya, Israel
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Tel Aviv, Israel
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Chūōku, Japan
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Kashiwa-shi, Japan
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Kōtoku, Japan
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Kurume-shi, Japan
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Kyoto, Japan
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Matsuyama, Japan
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Minatoku, Japan
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Nagoya, Japan
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Nakagami-gun, Japan
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Niigata, Japan
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Osaka, Japan
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Osaka, Japan
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Sapporo, Japan
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Shinjuku-ku, Japan
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Sunto-gun, Japan
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Toon-Shi, Japan
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Tsu, Japan
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Yokohama, Japan
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Kaunas, Lithuania
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Vilnius, Lithuania
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Vilnius, Lithuania
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Aguascalientes, Mexico
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México, Mexico
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Monterrey, Mexico
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Oaxaca City, Mexico
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Querétaro, Mexico
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San Luis Potosí City, Mexico
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Veracruz, Mexico
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Gdansk, Poland
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Lodz, Poland
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Lublin, Poland
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Olsztyn, Poland
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Olsztyn, Poland
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Anzorey, Russia
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Kazan, Tatarstan, Russia
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Krasnodar, Russia
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Moscow, Russia
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Moscow, Russia
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Saint Petersburg, Russia
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Saransk, Russia
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Sochi, Russia
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Singapore, Singapore
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Singapore, Singapore
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Singapore, Singapore
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Goyang-si, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Suwon, South Korea
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Yangsan, South Korea
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Barcelona, Spain
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Barcelona, Spain
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El Palmar, Spain
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Girona, Spain
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Jaén, Spain
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Madrid, Spain
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Mallorca, Spain