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Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever
Sponsor: Shanghai Jiao Tong University School of Medicine
Summary
This is a randomized study to evaluate the safety and feasibility of early de-escalation of empirical antibiotics treatment in neutropenic fever patients undergoing hematopoietic stem cell transplantation (HSCT). In case of afebrile for 72 hours with empirical antibiotics treatment, patients will be randomized into 2 groups. In the early de-escalation group, antibiotics treatment will be stopped and prophylaxis with levofloxacin will be resumed. In the control group, the empirical treatment will continue until recovery of neutropenia or at least for 7 days.
Official title: Phase III Randomized Study of Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever in Patients Undergoing Hematopoietic Stem Cell Transplantation
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2020-01-01
Completion Date
2026-06-30
Last Updated
2025-02-18
Healthy Volunteers
No
Conditions
Interventions
Early de-escalation
In de-escalating group, the empirical antibiotics will be stopped and then prophylaxis levofloxacin will be resumed.
Standard
In the control arm, empirical antibiotics will be continue until recpvery of neutropenia or at least 7 days after afebrile.
Locations (1)
Blood & Marrow Transplantation Center, RuiJin Hospital
Shanghai, Shanghai Municipality, China