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Molecular Characterization for Understanding Biliary Atresia
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Summary
Although considered a rare disease, Biliary Atresia (BA) is the leading cause of neonatal cholestasis and liver transplantation in children. Little is known about the molecular mechanisms that drive BA. The purpose of this study is to collect the fluid samples, explanted liver tissue samples and dermal biopsy samples to enable investigators to perform the genetic and molecular analyses that might point to the gene(s) and cellular pathway involved in etiology of BA disease.
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2021-02-07
Completion Date
2032-02-07
Last Updated
2021-06-04
Healthy Volunteers
Yes
Conditions
Interventions
blood sampling
collection of blood sample for preparation of DNA
skin biopsy sampling
preparation of primary cultures of dermal fibroblasts from skin biopsy sample
explanted liver of BA patients sampling
cryoconservation of liver tissue for molecular analyses
Locations (2)
Hopital Necker enfants malades
Paris, De, France
PRC Inserm
Paris, France