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Anticoagulation-free VV ECMO for Acute Respiratory Failure
Sponsor: Damian Ratano
Summary
Currently international experts recommend therapeutic anticoagulation for veno-venous extracorporeal membrane oxygenation (VV-ECMO). Reports and case series suggest that the absence of therapeutic anticoagulation is safe for VV-ECMO. No randomized control trials have assessed this. The aim of this pilot study is to assess safety and feasibility of an "anticoagulation-free strategy" for veno-venous ECMO (VV-ECMO) in Acute respiratory distress syndrome (ARDS).
Official title: Anticoagulation-free VV ECMO for Acute Respiratory Failure: A Pilot Safety and Feasibility Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2022-09-01
Completion Date
2027-01-30
Last Updated
2026-01-16
Healthy Volunteers
No
Interventions
Subcutaneous Heparin
The intervention group will receive prophylactic heparin instead of standard of care therapeutic intravenous heparin
Locations (1)
Toronto General Hospital
Toronto, Ontario, Canada