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RECRUITING
NCT04273880
PHASE1

Differences by Sex and Genotype in the Effects of Stress on Executive Functions

Sponsor: University of British Columbia

View on ClinicalTrials.gov

Summary

The aim of this project is to test the effects of an environmental factor (mild stress) on prefrontal cortex (PFC) and the cognitive functions that depend on PFC (collectively called executive functions \[EFs\]), and to test our predictions concerning how those effects differ by biological factors (hormones and genotype). To test our hypotheses concerning mechanism, the investigators will model the effects of mild stress on EFs pharmacologically. The purpose is to pharmacologically model the effects of mild stress on the cognitive functions (collectively called "executive functions" \[EFs\]) dependent on the frontal lobe. The investigators would also like to investigate how gender differences and genotype mediate the effect of methylphenidate (MPH) on EFs.

Key Details

Gender

All

Age Range

20 Years - 35 Years

Study Type

INTERVENTIONAL

Enrollment

146

Start Date

2018-04-28

Completion Date

2024-12

Last Updated

2024-05-08

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

Methylphenidate

10mg of MPH taken an hour and a half before one of the testing sessions.

DRUG

Vitamin C

90 mg of Vitamin C taken an hour and a half before the other testing session

Locations (1)

Developmental Cognitive Neuroscience Lab, Department of Psychiatry, University of British Columbia

Vancouver, British Columbia, Canada