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Differences by Sex and Genotype in the Effects of Stress on Executive Functions
Sponsor: University of British Columbia
Summary
The aim of this project is to test the effects of an environmental factor (mild stress) on prefrontal cortex (PFC) and the cognitive functions that depend on PFC (collectively called executive functions \[EFs\]), and to test our predictions concerning how those effects differ by biological factors (hormones and genotype). To test our hypotheses concerning mechanism, the investigators will model the effects of mild stress on EFs pharmacologically. The purpose is to pharmacologically model the effects of mild stress on the cognitive functions (collectively called "executive functions" \[EFs\]) dependent on the frontal lobe. The investigators would also like to investigate how gender differences and genotype mediate the effect of methylphenidate (MPH) on EFs.
Key Details
Gender
All
Age Range
20 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
146
Start Date
2018-04-28
Completion Date
2024-12
Last Updated
2024-05-08
Healthy Volunteers
Yes
Conditions
Interventions
Methylphenidate
10mg of MPH taken an hour and a half before one of the testing sessions.
Vitamin C
90 mg of Vitamin C taken an hour and a half before the other testing session
Locations (1)
Developmental Cognitive Neuroscience Lab, Department of Psychiatry, University of British Columbia
Vancouver, British Columbia, Canada