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Maternal Obesity and Offspring Neurodevelopment
Sponsor: Arkansas Children's Hospital Research Institute
Summary
Our goals are to characterize the effects of maternal obesity during pregnancy on infant brain development, reveal the neurodevelopmental consequences, and identify possible mechanisms causing these effects. Our overall hypothesis is that maternal obesity during pregnancy exposes the fetus to an inflammatory environment that affects infant brain structural and functional development and consequently neurodevelopmental outcomes. To test this hypothesis, the investigators will recruit normal-weight and obese pregnant women, examine inflammatory markers associated with obese pregnancy, and correlate them with offspring's brain development evaluated using quantitative MRI methods and outcomes evaluated using neurodevelopmental tests.
Official title: Maternal Obesity and Offspring Neurodevelopment: the MOON Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
260
Start Date
2019-10-03
Completion Date
2027-10-31
Last Updated
2025-12-15
Healthy Volunteers
Yes
Conditions
Locations (1)
Arkansas Children's Nutrition Center
Little Rock, Arkansas, United States