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ACTIVE NOT RECRUITING
NCT04274140

Maternal Obesity and Offspring Neurodevelopment

Sponsor: Arkansas Children's Hospital Research Institute

View on ClinicalTrials.gov

Summary

Our goals are to characterize the effects of maternal obesity during pregnancy on infant brain development, reveal the neurodevelopmental consequences, and identify possible mechanisms causing these effects. Our overall hypothesis is that maternal obesity during pregnancy exposes the fetus to an inflammatory environment that affects infant brain structural and functional development and consequently neurodevelopmental outcomes. To test this hypothesis, the investigators will recruit normal-weight and obese pregnant women, examine inflammatory markers associated with obese pregnancy, and correlate them with offspring's brain development evaluated using quantitative MRI methods and outcomes evaluated using neurodevelopmental tests.

Official title: Maternal Obesity and Offspring Neurodevelopment: the MOON Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

260

Start Date

2019-10-03

Completion Date

2027-10-31

Last Updated

2025-12-15

Healthy Volunteers

Yes

Conditions

Locations (1)

Arkansas Children's Nutrition Center

Little Rock, Arkansas, United States