Clinical Research Directory

The Inclusion Criteria: * Children must be 6 months to 59 months old * Adult participants 18 years of age or older scheduled for a standard of care endoscopy * EED manifesting as malnourishment (WHZ\<-2) without clear etiology or healthy subjects with WHZ \>=0 * Participants and/or parents/guardians must be able to give informed consent/assent * Participants and/or parents/guardians must be willing to provide consent for live streaming of the procedure * Participants must be able to follow fasting instructions prior to the procedure Inclusion criteria for Pregnant women: * Participants 18 years and older * Participants who are in their 2nd trimester of singleton pregnancy as confirmed by an ultrasound * Participants with a BMI below 18.5 without clear etiology and healthy pregnant women with BMI between 18.5 -24.5. * Participants must be able to follow fasting instructions prior to the procedure * Participants must be able to consent to the procedure Tethered Capsule Exclusion Criteria: * Participants with any history of esophageal or intestinal strictures or prior GI surgery * Participants with history of pyloric stenosis * Participants with HIV diagnosis Trans Nasal Exclusion Criteria: * Participants with any contraindications for NG/NJ tube placement, including but not limited to those listed below: * Participants with any history of esophageal or intestinal strictures or prior GI surgery * Participants with history of pyloric stenosis or atresia * Participants with suspected or diagnosed HIV, Hepatitis B and C * Participants with any history of esophageal or intestinal strictures or prior GI surgery * Participants with a history of upper gastrointestinal surgery including fundoplication * Participants with upper GI obstruction * Participants with short bowel syndrome * Participants with upper respiratory infection at least 7 days prior to the procedure * Deviated septum or any other anatomical abnormalities of the nasopharynx or upper gastrointestinal region, history of trans-sphenoidal surgery, facial or cranial trauma and fractures, chronic sinusitis, esophageal strictures, varices etc. * Participants on drugs which impair clotting like anticoagulants and antiplatelet drugs, NSAIDS, history of bleeding disorders. * Participants with upper GI bleeding Microbiome Brush Exclusion Criteria \- Participants with any contraindications to gastrointestinal biopsies as per standard of care For pregnant participants: * Participants with high-risk pregnancy conditions at the discretion of the subject's physician and the PI * Pregnant participants with a history of hyperemesis gravidarum * Pregnant participants with a history of severe anemia * Pregnant participants with gestational thrombocytopenia * Pregnant participants with Type 1 diabetes * Pregnant participants with Type 2 diabetes on medication and gestational diabetes requiring medication