Clinical Research Directory

Inclusion Criteria: * Children between 4 and 13 years; * With polyhandicap defined by association of the 5 following criteria: * Causal brain injury occurred before the age of 3 years * Severe or deep mental deficiency as defined by IQ \< 40, or no evaluable by the psychometric tests * Motor impairment: para / tetraparesis, hemiparesis, ataxia, or extrapyramidal motor disorders * Score of Gross Motor Function Classification System \[Palisano 1997\] is III, IV or V * Score of Functional Independence Measure \< 50; * Hospitalization in a clinical setting participating to the study; * Beneficiary of a social protection; * Written consent signed by personnel holding parental authority or legal representative. Exclusion Criteria: * Patient with progressive encephalopathies including metabolic origin, epileptic, or neurodegenerative diseases; * Planned to move in another clinical setting; * Foreseeable difficulty in the following up in the study.