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Pathogenic Study of Adult Immune Enteropathies
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Summary
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2020-02-27
Completion Date
2033-02-27
Last Updated
2025-09-18
Healthy Volunteers
Yes
Interventions
Blood sample collection; gastrointestinal biopsy
Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage...
Locations (4)
Hôpital Henri Mondor
Créteil, France
Hôpital Bicêtre
Le Kremlin-Bicêtre, France
Hôpital Saint Louis
Paris, France
Hôpital Cochin
Paris, France