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Identification of Pathways to Mitigate Immune-Related Adverse Events With Cancer Immunotherapy
Sponsor: National Jewish Health
Summary
This protocol is a prospective, observational study of participants receiving immunotherapy (checkpoint inhibitors, CPI) for cancer therapy, testing the hypothesis that patients with immune related cutaneous adverse events (ircAEs) have unique immunologic endotypes associated with polarized immune responses.
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
255
Start Date
2020-09-23
Completion Date
2026-02-28
Last Updated
2026-06-16
Healthy Volunteers
No
Conditions
Interventions
systemic corticosteroid or biologic
Treatment with systemic corticosteroids or biologic therapies (for corticosteroid refractory patients or these in which corticosteroids are not the treatment of choice)
Locations (3)
National Jewish Health
Denver, Colorado, United States
The Melanoma and Skin Cancer Institute
Denver, Colorado, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States