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Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples
Sponsor: Wake Forest University Health Sciences
Summary
The purpose of this research study is to evaluate if special types of cells called round spermatids can be gathered from men with non-obstructive azoospermia and used (in absence of elongated spermatids and spermatozoa) to reliably and effectively create pregnancy with a procedure called Round Spermatid Injection (ROSI). This process is similar to In Vitro Fertilization, or 'IVF'. In addition, this study wants to test the safety of ROSI and see what effects (good and bad) it has on embryo created from this method.
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2020-08-24
Completion Date
2026-07
Last Updated
2025-09-16
Healthy Volunteers
No
Conditions
Interventions
Round Spermatid Injection (ROSI)
In Vitro Fertilization using Round Spermatid Injection (ROSI)
Half ROSI-half Sperm Donor Fertilization
Half ROSI-half Sperm Donor Fertilization
Locations (1)
Carolinas Fertility Institute (CFI)
Winston-Salem, North Carolina, United States