Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Role of Oxytocin in the Second Stage of Labor
Sponsor: Washington University School of Medicine
Summary
This is a randomized controlled trial investigating the utility of oxytocin administration in the second stage of labor.
Official title: Role of Oxytocin in the Second Stage of Labor: a Randomized Controlled Trial (The ROSSoL Trial)
Key Details
Gender
FEMALE
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2022-07-01
Completion Date
2027-09-30
Last Updated
2026-01-05
Healthy Volunteers
Yes
Conditions
Interventions
Continue Oxytocin
The administration and titration of oxytocin for labor augmentation is per a hospital based protocol. To summarize, oxytocin is initiated intravenously at 2 milliunits/minute and increased by 2 milliunits/minute every 20 minutes until an adequate contraction pattern is attained or a maximum of 40 millunits/minute has been achieved. This protocol for titration and administration will be applied in this study to the oxytocin group. The intravenous pumps on Labor and Delivery have automated functions for intravenous administration of oxytocin that is milliunit-based and the same routine pumps will be used in this study. The study bag will be administered per current oxytocin protocol. Since patients will already be on oxytocin at time of randomization, their current bag of oxytocin will be continued by the primary provider at a rate of their discretion.
Discontinue Oxytocin
Patients will have their oxytocin discontinued in the second stage of labor. The patient will receive routine maintenance IV fluids per the discretion of the provider.
Locations (1)
Barnes Jewish Hospital
St Louis, Missouri, United States