Clinical Research Directory

Inclusion Criteria: * Female participants aged 18 to 52 years. * Primary diagnosis of cocaine use disorder according to DSM-5 criteria. Other co-occurring substance use disorders were permitted, provided that cocaine was the primary drug of choice. * Abstinence from cocaine for at least seven days before the intervention. * Provision of informed consent and willingness to undergo random allocation to one of the study groups. Exclusion Criteria: * HIV-positive status. * Pregnancy, postpartum status, or breastfeeding. * Menopause. * Current moderate or severe psychotic syndrome. * Treatment with corticosteroids, synthetic glucocorticoids, or other exogenous hormone or steroid therapy. * Intellectual impairment, defined as an intelligence quotient below 70. * An infectious condition or acute febrile syndrome. * Diagnosed or suspected neurological disease or syndrome, including current or previous stroke, epilepsy, cancer, or neurodegenerative disease. * Diagnosed or suspected autoimmune disease or syndrome. * Diagnosed or suspected current decompensated or severe cardiovascular, pulmonary, renal, gastrointestinal, or endocrine disease. * History of moderate or severe traumatic brain injury, specified in the manuscript as a Glasgow Coma Scale score below 12. * Significant nasal congestion preventing intranasal administration. * Type III nasal septal deviation with impaired breathing. * Nasal mucosal lesions. * Class III obesity. * History of any hysterectomy or bilateral oophorectomy.