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Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
Sponsor: East Carolina University
Summary
The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2020-03-03
Completion Date
2025-12
Last Updated
2025-08-07
Healthy Volunteers
No
Conditions
Interventions
Weight loss surgery
Severely obese women (BMI \>40) undergo sleeve gastrectomy
Locations (1)
East Carolina University
Greenville, North Carolina, United States