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Study of Circulating Monocytes in Patients With Ischemic Vascular Disease
Sponsor: UConn Health
Summary
The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type of monocyte carrying a surface marker called "P2X4" helps the immune system sense and respond to danger signals from the body such as heart muscle and brain tissue injuries. The researchers expect to learn more about how these monocyte cells react to heart and brain tissue injury, and how the cells may then produce proteins or other chemical substances which promote the healing of heart muscle after heart attack and brain tissue after an ischemic stroke.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2013-12-01
Completion Date
2027-12-01
Last Updated
2025-08-14
Healthy Volunteers
Yes
Interventions
There is no intervention given to the subjects
Not appicable
Locations (1)
University of Connecticut Health Center
Farmington, Connecticut, United States