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Tromsø Birch Rust Allergy Study. Allergy to Birch Rust, a Possible Explanation to Seasonal Airway Allergy During Autumn?
Sponsor: University Hospital of North Norway
Summary
In this project we study if spores from birch rust fungi (Melampsoridium Betulinum = MB) may be the eliciting allergen in patients with seasonal airway allergy during autumn in North Norway. Patients with suspected allergy to MB are compared with non-allergic controls using data about allergic disease and daily allergic symptoms during autumn. Daily spread of MB spores are compared with daily variations in allergic symptoms. Sensitization to MB and MB allergy are tested with skin prick test, specific immunoglobulin E (IgE) in serum, nasal provocation test and basophil activation test (BAT).
Official title: Tromsø Birch Rust Allergy Study. Allergy to Birch Rust Fungi, a Possible Explanation to Seasonal Airway Allergy During Autumn? A Pilot Study With 30 Patients With Suspected Allergy to Birch Rust and 15 Non-allergic Controls.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
48
Start Date
2020-08-01
Completion Date
2026-06-16
Last Updated
2026-06-17
Healthy Volunteers
No
Conditions
Interventions
MeDALL questionnaire for allergic diseases
Questionnaire about allergic symptoms and disease
Registration of allergic symptoms
Daily registration of allergic symptoms from eyes, nose and lungs on scale from 0-10 and daily registration of use of anti allergic medication from 1st of August to 15th of October.
Skin Prick Test
Diagnostic skin test for sensitization to allergens
Specific IgE in serum
Diagnostic test for sensitization to allergens in serum
Nasal provocation test
Diagnostic test for allergic rhinitis. Patients and controls are exposed to an allergen with a nasal spray. Allergic reactions are measured with Linder score and Pean Nasal Inspiratory Flow (PNIF)
Basophil Activation Test
Basophil leukocytes are extracted from full blood and exposed to 6 different doses of allergen and activation of basophils are measured.
Locations (1)
University Hospital of North Norway
Tromsø, Norway