Clinical Research Directory

Inclusion Criteria: * · Be able and willing to provide consent and sign the informed consent form. * Be able and willing to comply with study procedures and follow-up appointments required by the study protocol. * Age\>18 years * Presence of at least one implant affected with peri-implantitis, defined as the following con-dition: at least one site presenting peri-implant probing depth (PPD) \>6 mm and simultane-ous presence of profuse BoP/SUP and a radiographically documented change in bone level greater than initial bone remodeling. In the likely event that a baseline radiographic image is absent, the bone level will be compared to where it would likely have been at the time of implant insertion and a difference of \>3 mm from that level will be considered. * Implants in function (i.e. loaded) for at least 1 year. * Screw- and cement-retained suprastructures for both fixed and removable prostheses. Exclusion Criteria: * Compromised systemic health which contraindicates the study procedures. * Pregnant or nursing women. * Cigarette smoking\>5 per day * Systemic conditions compromising healing (i.e. diabetes mellitus). Patients with diabe-tes mellitus types I or II will be asked to provide information regarding their most re-cent HbA1c values. Only patients with HbA1c\<7% will be enrolled. * Patients taking medications known to interfere with gingival or bone metabolism.