Clinical Research Directory

Inclusion Criteria: * neonates with a term ≥ 36 weeks of amenorrhea and birth weight ≥ 1800 g. * presenting with perinatal asphyxia defined as combination of: * an acute perinatal event (such as placental abruption, cord prolapse, and/or severe foetal heart rate abnormalities); * and at least one of the following criteria: * Apgar score ≤ 5 at 10 minutes of life, * mask ventilation or intubation at 10 minutes of life, * metabolic acidosis defined as pH \< 7 or base deficit ≥ 16 mmol/L or lactates ≥ 11 mmol/L within the first 60 minutes of life on cord or other arterial venous or capillary blood sample. * patient treated or not with therapeutic hypothermia for 72 hours. * affiliated patient or beneficiary of a social security scheme. * informed and signed parental consent. Exclusion Criteria: * perinatal arterial ischemic stroke. * congenital neuro-metabolic disorder. * severe malformative abnormalities. * MRI contra-indication. * Poor understanding of the holders of parental authority