Clinical Research Directory

Inclusion Criteria * 19-25 or 35-45 years of age; * Use of smoked cannabis at least once in the past 6 months. * Use of smoked or vaped cannabis primarily for recreational purposes on up to 1 day per week or on at least 6 days per week in the past 3 months; * Holds a class G or G2 Ontario driver's licence (or equivalent from another jurisdiction) for at least 12 months; * Willing to abstain from using alcohol for 24 hours and cannabis for 72 hours prior to Practice and Test Sessions; * Willing to abstain from all other drugs not prescribed for medical purposes for 48 hours prior to Practice and Test Sessions; * Resides within Toronto (study site) or can reside with friends/family in Toronto after a Test Session; this area may be extended to the Greater Toronto area if recruitment challenges arise; * Participant willing to use appropriate contraception until their participation in the study is completed; * Provides written and informed consent. Exclusion Criteria * Use of cannabis primarily for therapeutic purposes, or equally for therapeutic and recreational purposes; * Diagnosis of medical condition that contraindicates use of cannabis determined by self-report as judged by the Principal Investigator and a study physician; this includes a history of hypersensitivity to cannabinoids smoke, respiratory disease and/or severe cardiovascular, cerebrovascular, renal or liver disease, and bleeding disorders. Smoking cannabis is not recommended for individuals with respiratory diseases, and they will be excluded; * Diagnosis of psychiatric condition that contraindicates use of cannabis determined by self-report or SCID-5; * Participants of childbearing potential: Pregnancy (point-of-care test) or breastfeeding; * Meets criteria for current or lifetime alcohol or other substance use disorder (DSM-5), except tobacco use disorder and caffeine use disorder; * Is a regular user of medications that affect brain function (based on self-report); this includes concomitant therapy with sedative-hypnotics or other psychoactive drugs * Use of anti-hypertensives; * First-degree relative diagnosed with schizophrenia or another psychotic disorder. * Participation in a past driving study at CAMH (to limit practice effects). * Participation in a clinical study concurrent with their participation in this study.