Clinical Research Directory
Browse clinical research sites, groups, and studies.
Single Dose Azithromycin to Prevent Cholera in Children
Sponsor: Massachusetts General Hospital
Summary
This study aims to determine whether single-dose azithromycin is effective in preventing cholera in children who are at extremely high risk of infection. The study will also determine the effect of this intervention on the development of antibiotic resistant bacteria. The results will inform future strategies to prevent cholera in children, and improve overall understanding of the impact of azithromycin on antibiotic resistance.
Official title: Azithromycin Prophylaxis in Child Contacts of Cholera Patients: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
1 Year - 15 Years
Study Type
INTERVENTIONAL
Enrollment
920
Start Date
2021-10-31
Completion Date
2026-05-31
Last Updated
2025-07-04
Healthy Volunteers
Yes
Conditions
Interventions
Azithromycin
Enrolled children in the intervention arm of this study will receive a single weight-based dose of azithromycin (20 mg/kg, to a maximum dose of 1 gram) administered by a trained study nurse within 12 hours of a member of their household testing positive for cholera.
Placebo
Enrolled children in the placebo arm of this study will receive a single dose of non-antibiotic placebo administered by a trained study nurse within 12 hours of a member of their household testing positive for cholera.
Locations (1)
icddr,b Dhaka hospital
Dhaka, Bangladesh