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Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
Sponsor: University of North Carolina, Chapel Hill
Summary
The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are that this reduction is driven by elevated non esterified fatty acids which act to turn on specific signaling pathways that regulate brain GLUT1 levels.
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2020-12-08
Completion Date
2026-06-01
Last Updated
2025-03-30
Healthy Volunteers
Yes
Conditions
Interventions
Intralipid, 20% Intravenous Emulsion
Infusion of Intralipid 20%
Placebos
saline 30 ml/hr for 12 hours through an IV
Locations (2)
Biomedical Research Imaging Center Marsico Hall (UNC)
Chapel Hill, North Carolina, United States
Clinical and Translational Research Center (CTRC) Burnett-Womack Building (UNC)
Chapel Hill, North Carolina, United States