Clinical Research Directory

Chronic Kidney Disease Subjects Inclusion Criteria Diabetic kidney disease (DKD) * Diagnosis of diabetes mellitus (type 1 or 2) established by at least one of the following criteria: * Hemoglobin A1C greater than or equal to 6.5%, confirmed with a repeat test within the past year * Fasting blood sugar greater than or equal to 126 mg/dL, confirmed with a repeat test within the past year * Use of glucose-lowering therapy (insulin or oral or other subcutaneous agents) * International Classification of Diseases (ICD) 9/10 diagnostic code for diabetes * Evidence of persistent kidney damage, manifest as any of the following present on at least two clinic assessments prior to enrollment and at least 3 months apart and excluding subjects with acute medical illnesses and changing kidney function: * Estimated glomerular filtration rate 30-59 mL/min/1.73m2 * Estimated glomerular filtration rate greater than or equal to 60 mL/min/1.73m2 with urine albumin excretion greater than or equal to 30 mg/g creatinine (or mg/day) * Estimated glomerular filtration rate greater than or equal to 60 mL/min/1.73m2 with urine protein excretion greater than or equal to 150 mg/g creatinine (or mg/day) Hypertension-associated Chronic Kidney Disease (H-CKD) Inclusion Criteria * Diagnosis of hypertension (HTN) established by at least one of the following criteria: * BP greater than 140/90 mmHg measured on three occasions over at least 1 month * Taking antihypertensive medication for blood pressure (BP) control * International Classification of Diseases (ICD) 9/10 diagnostic code for hypertension * Evidence of persistent kidney damage, manifested as any of the following present on at least two assessments at least 3 months apart and excluding subjects with acute medical illnesses and changing kidney function: * Estimated glomerular filtration rate 30-59 mL/min/1.73m2 on two assessments at least 3 months apart with albuminuria or proteinuria less than 2000 mg/g creatinine (or mg/day) * Estimated glomerular filtration rate greater than or equal to 60 mL/min/1.73m2 with urine albumin excretion 30-2000 mg/g creatinine (or mg/day) * Estimated glomerular filtration rate greater than or equal to 60 mL/min/1.73m2 with urine protein excretion 150-2000 mg/g creatinine (or mg/day) Acute Kidney Injury Subjects Inclusion Criteria All three of the following criteria must be met: * Baseline estimated glomerular filtration rate greater than 45 mL/min/1.73m2. Baseline defined by the median of the last three outpatient serum creatinine measurements from day 7 to 365 prior to enrollment. * If only two measurements obtained within this window, the two results will be averaged. * If only one measurement was obtained within this window, this result will be used * If baseline is missing the potential participant can be enrolled with an estimated baseline, but only if there is no past medical history of chronic kidney disease. * Elevated serum creatinine (greater than or equal to 1.5 times baseline as defined above). * And at least ONE of the following: * A repeat serum creatinine within 48 hours of initial serum creatinine, showing a further increase of 0.3 mg/dL * Positive kidney injury urine biomarker, as defined by any of the following: * NGAL level greater than or equal to 150 ng/mL by ELISA or clinical analyzer * KIM1 level greater than or equal to 2.8 ng/mL by ELISA * TIMP2 x IGFBP7 greater than or equal to 2.0 by NephroCheck® * Urine microscopy suggestive of acute tubular necrosis defined as a urine microscopy score of greater than or equal to 2. * greater than or equal to 1 Renal Tubular Epithelial cells (RTE) per high powered field (HPF) AND greater than or equal to 1 granular cast/ low powered field (LPF); or * greater than or equal to 5 Renal Tubular Epithelial cells (RTE) per high powered field (HPF); or * greater than or equal to 5 granular cast/ low powered field (LPF) General Exclusion Criteria: * Under 18 years of age * Body Mass Index (BMI) greater than 40 kg/m2 * Allergy to iodinated contrast (any reaction) * Pregnancy * Malignancy - Receiving active chemotherapy or radiation to treat malignancy (except for nephrectomy tissue for reference and feasibility studies) * Transplant recipient (includes solid transplant and bone marrow) * Additional vulnerable individuals (incarcerated, institutionalized, or otherwise unable to participate in the study) * Inability to provide informed consent * Clinical diagnosis of kidney disease from an autoimmune disease, dysproteinemia, viral disease or glomerular disease other than DKD or H-CKD * Unwilling to receive blood transfusion (if needed)