Clinical Research Directory

Inclusion Criteria: * Age 18-65 * Current diagnosis of major depressive disorder with or without dysthymic disorder according to DSM 5 criteria. * PHQ score ≥ 10. Note: Use of pharmacotherapy for depression and other psychiatric disorders during the intervention is allowed (with the exception of antipsychotic medication for psychotic disorder), as this reflects routine clinical care. Of note, in routine clinical care, it is not uncommon that antipsychotic medication is prescribed for symptoms in the depressive-anxious cluster rather than for primary psychotic symptoms. Exclusion Criteria: * Current psychotic symptoms or bipolar disorder. * Current use of antipsychotic medication specifically for the treatment of primary psychotic disorder. * Severe Personality Disorder (e.g., borderline personality disorder). * Historic or current self-injury/parasuicide of such extent and/or severity that may substantially interfere with the ability to engage in brief psychotherapy. * Current excessive use of drugs/alcohol. * Not fluent in Dutch. * Clinical contra-indication to brief psychotherapy (e.g., attachment history - multiple separations, serious ongoing trauma in childhood, multiple caregivers - suggesting the need for longer-term psychotherapy). * Evidence of pervasive use of help. * Highly unstable or insecure life arrangements. * No access to computer/internet or computer illiteracy. * Participation in another depression clinical trial within the last year where the participant has received CBT or PDT.