Clinical Research Directory

Inclusion Criteria: * Male and Female patients age 18 years or older * COVID-19 confirmed positive test results * High risk for complications including with Medium (5-6) or High (More than or equal to 7) NEWS score * Hematology criteria: ANC \>500 cells/mcl, HGB \>9 g/dl, Platelet count \>75,000/mcl * Metabolic criteria: Serum creatinine \<2.0 mg/dl or calculated creatinine clearance (using Cockcroft-Gault) \>30 ml/min, AST/ALT \<5x ULN AND Total Bilirubin WNL (for patients with Gilbert's disease, direct bilirubin \<ULN) Exclusion Criteria: * COVID-19 negative test result * Inability to adhere to study protocol requirements * Inability to provide informed consent * Other acute or chronic medical or psychiatric condition that in the judgment of the investigator would make the participant inappropriate to take part in the study * Pregnant and breastfeeding individuals * QTc interval greater than 470 msecs at baseline * History of hypersensitivity to atovaquone and/or azithromycin. * History of known intolerance to atovaquone and/or azithromycin