Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years old * Ejection fraction ≤ 35% * Symptomatic three vessel Coronary Artery Disease with target vessels that are amenable to bypass (as determined by the operating surgeon) or Left main disease * Adequate Distal target caliber (as determined by the PI or operating surgeon) Exclusion Criteria: * Exclusion criteria will include the existing contraindications to either Impella therapy or OPCABG revascularization: * Patients with structural heart disease requiring cardiopulmonary bypass * Patients with cardiogenic shock who require a period of short-term mechanical circulatory support * Patients with mechanical aortic valve * Patients with previous median sternotomy * Patients with evidence of non-viability on preoperative cardiac MRI or CT scan * Insufficient conduit * BMI over 50 * Suspected or known pregnancy