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Cognitive Control Emotion Training to Prevent Major Depression in Youth At-Risk
Sponsor: Hunan Normal University
Summary
The goal of this clinical trial is to learn if intervention of positive emotion working memory (PEWM), or negative emotion working memory (NEWM), or positive attention bias training (PABT) can prevent major depressive disorder (MDD) for the long-term effects of intervention in youth with depressive symptoms or with remitted MDD. The main questions it aims to answer are: * Does intervention PEWM, NEWM or PABT lower the MDD onset in youth with depressive symptoms or with remitted MDD? * How long does the intervention PEWM, NEWM or PABT can lower the MDD onset when taken an initial training added one booster training? * Which cognitive factors can predict MDD onset? Researchers will compare PEWM, NEWM, PABT to a placebo (a training that contains no active component) to see if the interventions work to prevent MDD. Participants will: * Take a PEWM, or a NEWM, or a PABT or a placebo nearly every day for 2 weeks with 10 sessions at initial. * Take a PEWM, or a NEWM, or a PABT or a placebo the day after tomorrow for 2 weeks with 8 sessions at 6 months follow-up. * Be interviewed by clinicians with standardized diagnostic schedules for affective disorders and schizophrenia for 5 years * Answer survey questions about depression-related symptoms for 5 years.
Official title: Cognitive Control Emotion Training to Prevent Major Depression in Youth At-Risk: A 5-Year Randomized Clinical Trial
Key Details
Gender
All
Age Range
16 Years - 21 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2019-10-15
Completion Date
2025-05-30
Last Updated
2026-08-10
Healthy Volunteers
No
Interventions
positive emotion working memory(PEWM) training
Participants take 10 sessions of positive emotion working memory training with n-bak task of positive words for two-week at itinal and 8 booster sessions at 6 months follow-up.
negative emtion working memory(NEWM) training
Participants take ten 16 × (21 + n) trial sessions of NEWM with dual n-back task with sad facial pictures for visual modality and sad words for auditory modality for 2 weeks at initial and 8 booster sessions for 2 weeks at 6 months follow-up.
PABT
Participants take ten 216-trial sessions of PABT with 90% probe dot fallen on positive words for 2 weeks and eight 216-trial booster sessions for 2 weeks at 6 months follow-up.
placebo (NABT)
Participants take ten 216-trial sessions of placebo training with 90% probe-dot fallen on neutral concrete words for 2 weeks at initial and 8 booster sessions for 2 weeks at 6 month follow-up.
Locations (1)
Department of Psychology, Hunan Normal University
Changsha, Hunan, China