Clinical Research Directory

Inclusion Criteria: * Age ≥ 5 years * Written informed consent provided * Individuals with FA must have a genetic confirmation of diagnosis and be biallelic for a GAA repeat length \> 55 in intron 1 of FXN and/or have a GAA repeat length \> 55 in intron 1 of FXN in one allele and another type of mutation that is inferred to cause loss of function in the second FXN allele * Individuals with FA must have an age of disease onset ≤ 25 years * Individuals with FA must have a disease duration ≤ 25 years * Individuals with FA must have a Friedreich Ataxia Rating Scale (FARS) Functional staging score of ≤ 5 and total modified FARS (mFARS) score of ≤ 65 on enrolment Exclusion Criteria: * Age \< 5 years * Unable to provide written informed consent * Magnetic resonance contraindications (e.g. pacemaker or other metallic surgical implants) * Presence of metallic dental braces * Pregnancy (ascertained via a question or test as mandated at particular sites) * Individuals with FA must not have acute or ongoing medical or other conditions that, after discussion between the Site Investigator and steering committee, is deemed to interfere with the conduct and assessments of the study * Individuals with FA must not have another neurological condition apart from FA * Individuals with FA must not have other neurologic conditions that, in the opinion of the Site Investigator, would interfere with the conduct and assessments of the study * Controls must not have a diagnosed psychiatric or neurological condition * Controls must not have acute or ongoing medical or other conditions that would interfere with the conduct and assessments of the study * Controls must not be siblings of individuals with FA whose carrier status (i.e., confirmed carrier, confirmed non-carrier, or obligate carrier) is unknown.