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Returning to Everyday Tasks Utilizing Rehabilitation Networks-III (RETURN-III)
Sponsor: VA Office of Research and Development
Summary
Millions of patients survive care in medical and surgical Intensive Care Units (ICUs) every year, only to suffer from a new or accelerated dementia-like process, called post-ICU long-term cognitive impairment (ICU-LTCI). ICU-LTCI causes considerable problems with personal relationships, return to work, and everyday tasks, such as managing medicines and money. No treatment for these patients is currently available. Technology using computerized cognitive rehabilitation could improve ICU-LTCI by harnessing the healing potential of the brain (i.e., neuroplasticity). This intervention is scalable, portable, and economical. The investigators will evaluate the effectiveness of computerized cognitive rehabilitation in a randomized controlled trial of 160 ICU survivors. The investigators hypothesize that this intervention could improve cognition. This research has high potential to influence rehabilitation strategies for Veteran and civilian ICU survivors.
Official title: Returning to Everyday Tasks Utilizing Rehabilitation Networks-III Pilot Randomized Clinical Trial (RETURN-III Pilot RCT)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2022-10-03
Completion Date
2027-07-31
Last Updated
2026-03-13
Healthy Volunteers
No
Interventions
Treatment Arm: Computerized Cognitive Rehabilitation
Treatment Arm: Computerized Cognitive Rehabilitation
Active Control computer games
Active Control computer games
Locations (2)
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Nashville, Tennessee, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States