Clinical Research Directory

Inclusion Criteria: * 1\) female, * 2\) ≥ 18 years old, * 3\) histologically confirmed metastatic breast cancer, with at least one positive hormone receptor (HR+) and HER2-, * 4\) first-line chemotherapy planned (or until 1 month after the chemotherapy has started) with intravenous (Paclitaxel or Doxorubicin or Cyclophosphamide or Carboplatin) or per os (Capecitabine or Vinorelbine) administration - NB : a patient who has previously received one or more lines of hormone therapy and who must start a 1st line of chemotherapy is eligible, * 5\) Eastern Cooperative Oncology Group (ECOG) Performance status ≤ 2, * 6\) life expectancy ≥ 3 months, * 7\) willing to be involved throughout the study, * 8\) ability to practice a adapted physical activity (APA) certified by a medical certificate issued by the referring oncologist or the clinical investigator, * 9\) using a compatible smartphone or Tablet PC to download the application ABLE02 and Withings Health Mate (from iOS 10 and android 6.0 and more recent), * 10\) Internet access, * 11\) valid health insurance affiliation, * 12\) able to read, write and understand French. Exclusion Criteria: * 1\) presence of unstable bone metastases or unconsolidated pathological fractures, * 2\) presence of central nervous system involvement with neurological deficits that prevent from walking, * 3\) presence of a history or co-existence of other primary cancer (except of in situ cancer regardless of the site and/or basal cell skin cancer and/or non-mammary cancer in complete remission for more than 5 years), * 4\) severe undernutrition (HAS) (i.e. for women ≤ 70 years old: a weight loss of ≥ 15% in 6 months or ≥10% in 1 month and for women over 70 years old: a weight loss of ≥ 15% in 6 months or ≥10% in 1 month, and body mass index \<18 kg/m²), * 5\) presenting a PA contraindication (e.g., uncontrolled hypertension, uncontrolled heart disease), * 6\) concurrent participation in another PA study, * 7\) unable to be followed for medical, social, family, geographical or psychological reasons throughout the study, * 8\) deprived of liberty by judicial or administrative decision, * 9\) pregnant.