Clinical Research Directory

Inclusion Criteria: * Part 1: * Patients who are diagnosed with ATAAD and received emergency surgery with ascending aortic replacement combined with open placement of triple-branched stent graft * elder than 60 years old * Preoperative PaO2/FiO2 ≥ 400mmHg, platelets ≥ 150\*109/L, bilirubin≥ 20μmol/L, no hypotension (without vasoactive drugs), Glasgow Coma Score Scale = 15, creatine ≥110μmol/L Part 2: * Patients who are diagnosed with ATAAD and received emergency surgery with ascending aortic replacement combined with open placement of triple-branched stent graft * Patients who have failure of at least 2 organs * Patients who meet the criteria as below: sequential organ failure assessment score (SOFA) ≥ 10 Exclusion Criteria: * • uncontrollable underlying disease life expectancy of less than 4 days history of long-term corticosteroid use during the past 6 months. * The pre-operative computer tomography angiography(CTA) demonstrate the visceral arteries are involved * pre-existing severe disease of any major organs