Clinical Research Directory

Inclusion Criteria: * 25-50 years, as age-related declines in brain connectivity occur starting around 40-45 years of age (49-51); * Participants must meet criteria for one of the following disorders according to Diagnostic and Statistical Manual of Mental Disorders-5 criteria (52): major depressive disorder (MDD), persistent depressive disorder (PDD), bipolar disorder (BD) type I/type II, cyclothymia. To ensure adequate representation across diagnostic categories (including controls), the investigators will cap enrollment of major mood disorders (MDD, BD type I/II) to 50%, PDD and cyclothymia to 25% and recruit a healthy comparison group to comprise the remaining 25% of the sample. * Own a BiAffect-compatible smartphone. Exclusion Criteria: * Active suicidal ideation as determined by the Columbia Suicide Severity Rating Scale (C-SSRS)(50), suicide attempt in the last 3 months * Severe cognitive impairment secondary to a neurological disorder (mild cognitive impairment, neurocognitive disorders, traumatic brain injury, developmental delay) * Active moderate or severe alcohol and/or substance use disorders; * Major medical or neurologic illness that would interfere with protocol adherence and/or interpretation of findings; and * Presence of contraindications to MRI. * Pregnancy (positive pregnancy test), trying to become pregnant, or lactation.