Clinical Research Directory

Inclusion Criteria: * Patients 18 years or older * Diagnosis of SARS-CoV-2 infection by RT-PCR * Diagnosis of serious or critical illness, without mechanical ventilation or with less than 24 hours of mechanical ventilation. * Severe: dyspnea, increase in respiratory rate ≥ 30 breaths / min, oxygen saturation \<90% or PaO2 \<60 mmHg or increase in supplemental oxygen requirement more than 3% from baseline, PaO2 / FiO2 \<300 mmHg, and / or pulmonary infiltrates by image\> 50% within 24 to 48 hours of symptom onset. * Critical: respiratory failure (alteration in gas exchange with PaO2 \<60 mmHg with or without elevation of PaCO2\> 33 mmHg), septic shock (hypotension secondary to sepsis with a requirement for vasopressors to maintain a mean arterial pressure\> 65 mmHg and lactate\> 2 mmol / l). * Signature of informed consent by the patient, family member or legal representative * Negative pregnancy test for women of childbearing age. * Male patients who agree to use barrier methods when having sexual intercourse in the following 80 days after receiving tocilizumab * Patients receiving immunomodulatory treatment (cancer, transplant recipients or other diseases) that may temporarily suspend the drug. Exclusion Criteria: * Pregnant or lactating women. * Patients who by indication of their treating doctor cannot suspend previous immunomodulatory treatment. * Known allergic reactions to Tocilizumab or any excipients. * Patients receiving systemic steroids at a dose greater than 1 mg / Kg of weight per day in prednisone equivalents * Patients with SOFA score\> 15 points that predicts 90% mortality on admission * The decision of the attending physician not to include the patient due to the presence of any condition that does not allow the administration of the drug to be safe. * Diverticulitis or intestinal perforation * Patients with any of the following active infections: viral hepatitis, tuberculosis, HIV infection, bacterial and/or fungal and/or viral infections (other than SARS-CoV-2 infection) suspected or diagnosed using compatible microbiological isolation. * Alanine aminotransferase/aspartate aminotransferase values\> 5 times the upper limit of normal * Neutrophil values \<1000/ml, * Platelet values \<50,000/ml.