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Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome
Sponsor: McMaster University
Summary
Most patients suffering from the irritable bowel syndrome (IBS) report that ingestion of certain foods is a major trigger of symptoms, but the reason is unclear. Previous studies have shown that foods containing poorly absorbed carbohydrates (FODMAPs) are fermented by the bacteria in our bowels and these cause symptoms in some but not all patients. Gut bacteria are capable of producing various products, such as neuroimmune mediator histamine, that may be related to IBS symptoms. Our recent data suggest that consumption of FODMAPs promotes production of bacterial histamine. The main objective of this study is to investigate bacterial production of histamine and its relationship to IBS symptoms. The study will involve 6 weeks on a low-FODMAP diet with three three-day interventions consisting of High- or Low-FODMAP drinks along with probiotics or placebo capsules. The patient's bacteria and metabolites will be analyzed at various time points.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2021-07-15
Completion Date
2026-02-10
Last Updated
2026-04-13
Healthy Volunteers
No
Conditions
Interventions
L-Histidine
1 capsule (0.6g) twice daily
High-FODMAP beverage
High-FODMAP beverage (10g of fermentable carbohydrates) consumed twice daily.
Low-FODMAP beverage
Low-FODMAP beverage (10g glucose) consumed twice daily.
Lactobacillus acidophilus CL1285, L. casei LBC80R and L. rhamnosus CLR2.
Total of 50 billion CFU/capsule taken twice daily.
Placebo
Enteric coated capsule with no active ingredient, taken twice daily
Locations (2)
McMaster University Medical Centre
Hamilton, Ontario, Canada
Kingston Health Sciences Centre
Kingston, Ontario, Canada