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NCT04365387
PHASE2

A Study to Assess Immunization Responses in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Treated With Nemolizumab

Sponsor: Galderma R&D

View on ClinicalTrials.gov

Summary

The purpose of this study is to assess the effect of nemolizumab (CD14152) on humoral immune responses to tetanus and meningococcal vaccination in adult and adolescent participants with moderate-to-severe atopic dermatitis (AD).

Official title: A Randomized, Double-Blind, Placebo-Controlled Study to Assess Immunization Responses in Adult and Adolescent Subjects With Moderate-to-Severe Atopic Dermatitis Treated With Nemolizumab

Key Details

Gender

All

Age Range

12 Years - 54 Years

Study Type

INTERVENTIONAL

Enrollment

242

Start Date

2020-03-05

Completion Date

2023-07-07

Last Updated

2026-06-01

Healthy Volunteers

No

Interventions

DRUG

Nemolizumab

Nemolizumab was administered by 2 SC injections as 60-mg loading dose at baseline and a single 30-mg dose at Weeks 4, 8, and 12.

DRUG

Placebo

Placebo was administered by 2 SC injections at baseline and a single dose at Weeks 4, 8, and 12.

Locations (64)

Galderma Investigational Site (Site#9922)

Phoenix, Arizona, United States

Galderma Investigational Site (Site#8873)

Scottsdale, Arizona, United States

Galderma Investigational Site (Site#8447)

Fort Smith, Arkansas, United States

Galderma Investigational Site (Site#8831)

Anaheim, California, United States

Galderma Investigational Site (Site#8854)

Canoga Park, California, United States

Galderma Investigational Site (Site#8578)

Cerritos, California, United States

Galderma Investigational Site (Site#8791)

Fresno, California, United States

Galderma Investigational Site (Site#8845)

Huntington Beach, California, United States

Galderma Investigational Site (Site#8833)

Inglewood, California, United States

Galderma Investigational Site 2 (Site#8833)

Inglewood, California, United States

Galderma Investigational Site (Site#8858)

Long Beach, California, United States

Galderma Investigational Site (Site#8130)

Los Angeles, California, United States

Galderma Investigational Site (Site#8813)

Los Angeles, California, United States

Galderma Investigational Site (Site#8837)

Pomona, California, United States

Galderma Investigational Site (SIte#8870)

Boca Raton, Florida, United States

Galderma Investigational Site (Site#8786)

Clearwater, Florida, United States

Galderma Investigational Site (Site#8792)

Doral, Florida, United States

Galderma Investigational Site (Site#8391)

Hialeah, Florida, United States

Galderma Investigational Site (Site#8836)

Jacksonville, Florida, United States

Galderma Investigational Site (Site#8850)

Margate, Florida, United States

Galderma Investigational Site (Site#8851)

Miami, Florida, United States

Galderma Investigational Site (Site#9921)

Miami Lakes, Florida, United States

Galderma Investigational Site (Site#8840)

Ocoee, Florida, United States

Galderma Investigational Site (Site#8788)

Orlando, Florida, United States

Galderma Investigational Site (Site#8213)

Ormond Beach, Florida, United States

Galderma Investigational Site (Site#8856)

Ormond Beach, Florida, United States

Galderma Investigational Site (Site#8856)

Ormond Beach, Florida, United States

Galderma Investigational Site (Site#8843)

Sweetwater, Florida, United States

Galderma Investigational Site (Site#8764)

Tampa, Florida, United States

Galderma Investigational Site 2 (Site#8816)

Tampa, Florida, United States

Galderma Investigational Site (Site#8839)

Tampa, Florida, United States

Galderma Investigational Site (Site#8739)

Normal, Illinois, United States

Galderma Investigational Site (Site#8142)

Indianapolis, Indiana, United States

Galderma Investigational Site (Site#8532)

Overland Park, Kansas, United States

Galderma Investigational Site (Site#8812)

Metairie, Louisiana, United States

Galderma Investigational Site (Site#8793)

Towson, Maryland, United States

Galderma Investigational Site (Site#8033)

Clinton Township, Michigan, United States

Galderma Investigational Site (Site#8129)

Fort Gratiot, Michigan, United States

Galderma Investigational Site (Site#8849)

Troy, Michigan, United States

Galderma Investigational Site (Site#8876)

Bridgeton, Missouri, United States

Galderma Investigational Site (Site#8847)

Las Vegas, Nevada, United States

Galderma Investigational Site (Site#8848)

Las Vegas, Nevada, United States

Galderma Investigational Site 2 (Site#8864)

Las Vegas, Nevada, United States

Galderma Investigational Site (Site#8420)

Portsmouth, New Hampshire, United States

Galderma Investigational Site (Site#9924)

Raritan, New Jersey, United States

Galderma Investigational Site (Site#8828)

Kew Gardens, New York, United States

Galderma Investigational Site (Site#9919)

Raleigh, North Carolina, United States

Galderma Investigational Site (Site#8795)

Shelby, North Carolina, United States

Galderma Investigational Site (Site#8857)

Oklahoma City, Oklahoma, United States

Galderma Investigational Site (Site#8841)

Medford, Oregon, United States

Galderma Investigational Site (Site#8428)

Philadelphia, Pennsylvania, United States

Galderma Investigational Site (Site#8353)

Yardley, Pennsylvania, United States

Galderma Investigational Site (Site#8777)

Charleston, South Carolina, United States

Galderma Investigational Site (Site#8200)

Goodlettsville, Tennessee, United States

Galderma Investigational Site (Site#8846)

Austin, Texas, United States

Galderma Investigational Site (Site#8855)

Beaumont, Texas, United States

Galderma Investigational Site (Site#8245)

Dallas, Texas, United States

Galderma Investigational Site (Site#8868)

Houston, Texas, United States

Galderma Investigational Site (Site#8817)

Katy, Texas, United States

Galderma Investigational Site (Site#8787)

Plano, Texas, United States

Galderma Investigational Site (Site#8329)

San Antonio, Texas, United States

Galderma Investigational Site (Site#8003)

Webster, Texas, United States

Galderma Investigational Site (Site#8844)

Orem, Utah, United States

Galderma Investigational Site (Site#9935)

Springville, Utah, United States