Clinical Research Directory
Browse clinical research sites, groups, and studies.
Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis
Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Summary
The purpose of this study is to determine the efficacy of adjuvant HIPEC with Mitomycin C after colectomy in the treatment of colorectal cancer patients at high risk of peritoneal carcinomatosis.
Official title: A Multicenter Prospective Randomized Controlled Clinical Trial of Hyperthermic Intraperitoneal Chemotherapy After Colectomy in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
688
Start Date
2020-06-04
Completion Date
2026-04-30
Last Updated
2020-06-16
Healthy Volunteers
No
Conditions
Interventions
Radical colectomy
Patients undergo radical resection of the primary colorectal cancer(open or laparoscopic/robotic)
HIPEC
HIPEC(simultaneously or within 2days after resection) with mitomycin c (30 mg/m2) at 43°C for 90 minutes.
Systemic chemotherapy
Systemic chemotherapy regimens: CapeOx and mFOLFOX6 are preferred for stage Ⅲ patients. CapeOx:oxaliplatin 130 mg/m2 IV d1 + capecitabine 1000mg/m2 po bid d1-14. Repeat every three weeks for eight cycles. mFOLFOX6:oxaliplatin 85 mg/m2 IV d1 + leucovorin calcium 400 mg/m2 IV d1 + 5-FU 400 mg/m2 IV bolus d1 + 5-FU 2400 mg/m2 continuous IV over 46-48 hours d1-2. Repeat every two weeks for twelve cycles. For stageⅡpatiens, regimens recommend by NCCN guide line(2019 v1) are acceptable.
Locations (37)
Peking University People's Hospital
Beijing, Beijing Municipality, China
Beijing Hospital
Beijing, Beijing Municipality, China
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Peking University Cancer Hospital & Institute
Beijing, Beijing Municipality, China
Chongqing Cancer Hospital
Chongqing, Chongqing Municipality, China
First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
The First People's Hospital of FoShan (Affiliated FoShan Hospital of Sun Yat-sen University)
Foshan, Guangdong, China
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Guangdong Provincal people's Hospital
Guangzhou, Guangdong, China
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Guangzhou, Guangdong, China
Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, China
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
The Six Affiliated Hospital,Sun Yat-sen University
Guangzhou, Guangdong, China
JiangMen Central Hospital Affiliated JiangMen Hospital Of SUN YAT-SEN University
Jiangmen, Guangdong, China
MeiZhou People's Hospital
Meizhou, Guangdong, China
Affiliated Shantou Hospital of Sun Yat-sen University
Shantou, Guangdong, China
Shenzhen Second People's Hospital
Shenzhen, Guangdong, China
Zhongshan City People's Hospital
Zhongshan, Guangdong, China
Zhuhai People's Hospital, Zhuhai hospital affiliated with Jinan University
Zhuhai, Guangdong, China
People's hospital of guangxi zhuang autonomous region
Nanning, Guangxi, China
The Affiliated Tumor Hospital of Guangxi Medical University
Nanning, Guangxi, China
Hebei Medical University Fourth Hospital
Shijiazhuang, Hebei, China
Union Hospital,Tongji Medical College, Huazhong Uninersity of Science and Technolgy
Wuhan, Hubei, China
Wuhan University Renmin Hospital
Wuhan, Hubei, China
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China
the First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
The Third Peoples' Hospital of Chengdu
Chengdu, Sichuan, China
West China Hospital，Sichuan University
Chengdu, Sichuan, China
People'S Hospital of Deyang City
Deyang, Sichuan, China
Leshan people's Hospital
Leshan, Sichuan, China
The Affiliated hospital of southwest medical university
Luzhou, Sichuan, China
The Second Affiliated Hospital，Zhejiang University School of Medicine
Hangzhou, Zhejiang, China