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Intensive Rhythm Monitoring to Decrease Ischemic Stroke and Systemic Embolism - the Find-AF 2 Study
Sponsor: University of Leipzig
Summary
Patients who have suffered a stroke are having an increased risk of having recurrent stroke in the future. This risk of stroke is increased by atrial fibrillation, which often "comes and goes" (called paroxysmal) and hence escapes routine diagnostics. The hypothesis of Find-AF 2 is that enhanced (evaluation in a ECG core lab), prolonged (at least 7 days of rhythm monitoring annually) and intensified (continuous rhythm monitoring in high risk patients) not only finds atrial fibrillation more often, but that changes in therapeutic management (e. g. start of anticoagulation after detection of atrial fibrillation) results in a decrease of cardioembolism (which can be either recurrent stroke or systemic embolism). To prove this hypothesis, patients will be randomised into two groups: the first group will receive the currently available standard care for patients with stroke. In the second group, cardiac rhythm monitoring adapted to the risk of the occurrence of atrial fibrillation is performed - either with a 7-day long-term ECG (at baseline, after 3 and 12 months and every 12 months thereafter) or with continuous monitoring using an implantable cardiac monitor. If atrial fibrillation is detected, this information will be given to the treating study physician. Any therapeutic decision is at the discretion of the treating physician, but should follow current guidelines.
Official title: Intensive Heart Rhythm Monitoring to Decrease Ischemic Stroke and Systemic Embolism - the Find-AF 2 Study
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
5227
Start Date
2020-07-07
Completion Date
2026-12-31
Last Updated
2025-06-04
Healthy Volunteers
No
Conditions
Interventions
7-day Holter ECG
7-day Holter ECG at baseline and after 3 and 12 months and then annually until the end of the study or the first (in patients with low risk of atrial fibrillation)
Implantable cardiac monitor
Continuous rhythm monitoring using an implantable cardiac monitor
Standard of care
Usual care according to current guidelines (in patients with low and high risk of atrial fibrillation)
Locations (52)
ISD München
München, Bavaria, Germany
Klinikum Nürnberg
Nuremberg, Bavaria, Germany
Klinikum Bremen Mitte
Bremen, City state Bremen, Germany
University of Leipzig, Clinic for Neurology
Leipzig, Saxony, Germany
Vivantes Klinikum Neukölln Berlin
Berlin, State of Berlin, Germany
Klinikum Altenburger Land
Altenburg, Germany
Klinikum Aschaffenburg-Alzenau
Aschaffenburg, Germany
Universitätsklinikum Augsburg
Augsburg, Germany
Rhön Klinikum Campus Bad Neustadt
Bad Neustadt an der Saale, Germany
Sozialstiftung Bamberg; Klinikum am Bruderwald
Bamberg, Germany
BG Klinikum, Unfall-KH Berlin gGmbH
Berlin, Germany
Vivantes, Humboldt-Klinikum Berlin
Berlin, Germany
Vivantes Klinikum Spandau
Berlin-Spandau, Germany
Evangelisches Klinikum Bethel, Klinik für Neurologie
Bielefeld, Germany
Universitätsklinikum Bonn
Bonn, Germany
Klinikum Coburg, Medizinische Klinik für Innere Medizin und Kardiologie
Coburg, Germany
Klinikum Darmstadt
Darmstadt, Germany
Städtisches Klinikum Dresden, Standort Friedrichstadt
Dresden, Germany
Universitätsklinikum Carl Gustav Carus
Dresden, Germany
Universitätsklinikum Erlangen
Erlangen, Germany
University of Essen, Clinic for Neurology
Essen, Germany
Klinikum Frankfurt Höchst
Frankfurt, Germany
Universitätsklinikum Frankfurt
Frankfurt, Germany
Klinikum Fulda
Fulda, Germany
Universitätsklinikum Gießen und Marburg GmbH
Giessen, Germany
University of Göttingen, Clinic for Neurology
Göttingen, Germany
Bezirkskrankenhaus Günzburg
Günzburg, Germany
Krankenhaus Martha-Maria Halle-Dölau
Halle, Germany
Albertinenkrankenhaus Hamburg
Hamburg, Germany
Asklepios Klinik Altona Hamburg
Hamburg, Germany
Asklepios Klinik Wandsbek, Hamburg
Hamburg, Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Universitätsklinikum Heidelberg
Heidelberg, Germany
Klinikum Höxter
Höxter, Germany
Klinikum Ibbenbüren
Ibbenbueren, Germany
Klinikum St. Georg Leipzig
Leipzig, Germany
Städtisches Klinikum Lüneburg gemeinnützige GmbH
Lüneburg, Germany
University of Mainz, Clinic for Neurology
Mainz, Germany
Carl-von-Basedow Klinikum Merseburg
Merseburg, Germany
Klinikum Minden
Minden, Germany
Ökumenisches Hainich Klinikum Mühlhausen
Mühlhausen, Germany
Universitätsklinikum Münster
Münster, Germany
Klinikum Osnabrück GmbH
Osnabrück, Germany
Klinikum Passau
Passau, Germany
Nordwest-Krankenhaus Sanderbusch, Klinik für Neurologie
Sande, Germany
Kreisklinikum Siegen
Siegen, Germany
Kliniken Südostbayern AG, Klinikum Traunstein
Traunstein, Germany
Universitätsklinikum Tübingen
Tübingen, Germany
Universitätsklinikum Ulm
Ulm, Germany
Helios Dr. Horst Schmidt-Kliniken Wiesbaden
Wiesbaden, Germany
Universitätsklinikum Würzburg
Würzburg, Germany