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Personalized Second Chance Breast Conservation (PSCBC): A Prospective Phase II Clinical Study
Sponsor: Weill Medical College of Cornell University
Summary
The goal of the study is to investigate the feasibility of enabling a second chance for breast conservation in patients with in-breast recurrences after a previous lumpectomy and RT, investigators propose to test partial breast irradiation with the target volume encompassing the entire surgical bed with 1.0-1.5 cm margins. An additional goal of the study is to investigate the feasibility of enabling a second chance for breast conservation in patients with inbreast recurrences after a previous lumpectomy and PBI, the investigators propose to test whole breast RT (WBRT) with the target as the whole breast volume.
Official title: Personalized Second Chance Breast Conservation (PSCBC): A Two Center Prospective Phase II Clinical Study
Key Details
Gender
FEMALE
Age Range
19 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2020-06-30
Completion Date
2035-12-31
Last Updated
2026-01-27
Healthy Volunteers
No
Conditions
Interventions
600cGY x 5 fractions APBI
Patients will be treated with the fractionation of 30 Gy in 5 fractions over 1-2 weeks, which is the accelerated fractionation scheme of choice for RT naïve patients at New York Presbyterian using EBRT
270cGy x 15 fractions WBRT
Patients will be treated with the fractionation of 4050 cGy in 15 fractions over 3 weeks, which is the standard whole breast RT (WBRT) fractionation scheme of choice for RT naïve patients at New York Presbyterian using External Beam Radiation Therapy (EBRT)
Locations (3)
New York Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, United States
New York Presbyterian Hospital - Queens
New York, New York, United States
Weill Cornell Medicine
New York, New York, United States