Clinical Research Directory

Inclusion Criteria: Body dysmorphic disorder: Inclusion: * males or females * ages 18-40 * meet Diagnostic and Statistical Manual-5 (DSM-5) criteria for Body Dysmorphic Disorder * have a Body Dysmorphic Disorder version of the Yale-Brown Obsessive-Compulsive Disorder Scale (BDD-YBOCS) score of ≥20 * primary appearance concerns of the face or head area * medication naïve or medication free for at least 8 weeks prior to enrollment Inclusion Criteria: Subclinical body dysmorphic disorder: Inclusion: * males or females * ages 18-40 * have a score on the Dysmorphic Concern Questionnaire of ≥8 \[1 standard deviation (STD) above population norms\] - primary appearance concerns of the face or head area * medication naïve or medication free for at least 8 weeks prior to enrollment Inclusion Criteria: Healthy controls: Inclusion * Healthy males and females from any racial or ethnic background - ages 18-40 * have a score on the Dysmorphic Concern Questionnaire of \<8 Exclusion Criteria: Body dysmorphic disorder: Exclusion * concurrent major Axis I disorders including substance use disorders, aside from anxiety disorders or depressive disorders, as these comorbidities are very common and the sample would otherwise be non-representative; however BDD must be the primary diagnosis. * lifetime: bipolar disorder or psychotic disorder. * psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken on the days of the training or MRI scan * current cognitive-behavioral therapy Exclusion: Subclinical body dysmorphic disorder: Exclusion * meet full DSM-5 criteria for Body Dysmorphic Disorder * current Axis I disorders including substance use disorders * lifetime: bipolar disorder or psychotic disorder * psychotropic medications, aside from a short half-life sedative/hypnotic for insomnia, or a short half-life benzodiazepine as needed for anxiety but not exceeding a frequency of 3 doses in one week and not to be taken on the days of the training or MRI scan * current cognitive-behavioral therapy Exclusion Criteria: Healthy Controls: Exclusion * Any current Axis I disorder * lifetime: bipolar disorder or psychotic disorder * Psychiatric medication Exclusion Criteria: All participants: Exclusion * Neurological disorder * Pregnancy * Current major medical disorders that may affect cerebral metabolism such as diabetes or thyroid disorders - Current risk of suicide with a plan and intent * Ferromagnetic metal implantations or devices (electronic implants or devices, infusion pumps, aneurysm clips, metal fragments or foreign bodies, metal prostheses, joints, rods or plates) * Visual acuity worse than 20/35 for each eye as determined by Snellen close vision acuity chart (vision will be tested with corrective lenses if participant uses them).