Clinical Research Directory

Inclusion Criteria: * Male or female subjects ≥ 18 years of age * Must be newly diagnosed with GBM * Primary treatment must consist of a chemoradiation therapy (CRT) regimen * Hemoglobin \> 9 g/dL * White blood count 3,600 - 11,000/mm3 * Absolute neutrophil count (ANC) ≥ 1,500/mm3 * Absolute lymphocyte count (ALC) ≥ 1,000/mm3 * Platelet count 100,000/mm3 * BUN ≤ 1.5 times upper limit of normal * Creatinine clearance rate \> 40 mL/min * ALT ≤ 3 times upper limit of normal * AST ≤ 3 times upper limit of normal * Alkaline phosphatase ≤ 3 times upper limit of normal * Total bilirubin ≤ 2.0 mg/dL * Karnofsky Performance Status ≥ 70 * Must not be on any other alternative therapies * Not pregnant Exclusion Criteria: * Known hypersensitivity to meloxicam, famotidine, and/or caffeine or any of their derivatives or components * Known allergy to vitamin A, vitamin D3, and/or L-citrulline * Pregnant women * Breastfeeding women * Corticosteroid therapy that cannot be tapered down to a dose of 1 - 2 mg/day of dexamethasone or its equivalent * History of immunodeficiency diseases or autoimmune diseases * History of peptic ulcer disease or gastrointestinal perforation