Inclusion Criteria D-dimer:
* Subjects \>18 years of age.
* Willing and able to provide written informed consent and comply with study procedures.
* Presenting to healthcare provider for any reason\* \*All presentations are suitable for recruitment; however, the following conditions are of particular interest: Venous thromboembolism symptoms (DVT and Pulmonary embolism), subjects seeking medical attention with symptoms of respiratory tract infection (upper or lower), Acute myocardial infarction / unstable angina, Anti-inflammatory medication (current), Any regular medication for a chronic condition (other than simple painkiller or inhaler), Atrial fibrillation, Diabetes mellitus (all types except 'pre-diabetes'), Heart failure, Hypertension (\>150/90), Infection (significant current or within 3 months), Peripheral arterial disease, Surgery (within 6 weeks), Childbirth (within 8 weeks), Significant trauma, burns (within 4 weeks), Pregnancy (confirmed or suspected), Acute upper gastrointestinal haemorrhage other significant recent haemorrhage.
D-dimer Exclusion Criteria:
* The subject is currently receiving or has received within the past thirty (30) days of the study visit an experimental biologic or drug including either treatment or therapy.
* Skin lesions or conditions that would preclude a fingerstick and or a venous blood draw.
* End-stage renal failure on haemodialysis.
* Life expectancy documented as less than 30 days.
* Haemodynamically unstable (e.g. cardiogenic shock).
* Current anticoagulation therapy (Fragmin, LMWH) within the last 30 days.
* Patients taking anticoagulant therapy (DOACS, Warfarin, Heparins etc.) within the last 30 days.
* The subject has previously participated in this research study
CRP Inclusion criteria:
* Subjects \>18 years of age.
* Willing and able to provide written informed consent and comply with study procedures.
* Subjects seeking medical attention with symptoms of infection, tissue injury, inflammatory disorders or associated disease. This includes but not limited to: respiratory tract infection (upper or lower), rheumatoid arthritis, Lupus, burns, trauma, inflammatory bowel disease.
CRP Exclusion Criteria:
* The subject is currently receiving or has received within the past thirty (30) days of the study visit an experimental biologic or drug including either treatment or therapy.
* Skin lesions or conditions that would preclude a fingerstick and or a venous blood draw.
* A subject with a critical illness, requiring critical intervention, or end of life or palliative care.
* Subjects suffering with Myeloma, Monoclonal Gammopathy or extreme Lipaemia.
* The subject has previously participated in this research study
