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Precision Guided Tacrolimus Dosing in Pediatric Heart Transplant
Sponsor: University of Utah
Summary
Immunosuppressive therapy is required to prevent organ rejection, however, dosing of immunosuppressive agents is complicated by patient-specific differences impacting the body's absorption and elimination of these agents. The goal of this research proposal is to clinically validate an innovative precision medicine strategy for dosing the immunosuppressant tacrolimus in pediatric heart transplant, which will in turn lead to improvements in long-term transplant survival outcomes. The strategy and techniques used in this project can be extended to improve drug therapy across multiple pediatric diseases requiring chronic therapy.
Official title: Precision Pharmacokinetic-Guided Tacrolimus Dosing to Improve Pediatric Heart Transplant Outcomes
Key Details
Gender
All
Age Range
6 Months - 18 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2020-05-01
Completion Date
2025-04-30
Last Updated
2025-01-07
Healthy Volunteers
No
Conditions
Interventions
Tacrolimus Dosing Support Tool
The tacrolimus dosing support tool is based on a population pharmacokinetic model that incorporates patient specific factors including age, renal function, and concomitant medications.
Locations (2)
Primary Children's Hospital
Salt Lake City, Utah, United States
University of Utah
Salt Lake City, Utah, United States