Clinical Research Directory

Inclusion Criteria: * at least 6 months since stroke * single cortical or subcortical ischemic stroke * able to walk 10-meters with or without assistive device * sufficient cardiovascular health and ankle stability to walk on treadmill for 2-minutes at self-selected speed without orthosis * resting heart rate 40-100 bpm Exclusion Criteria: * hemorrhagic stroke * cerebellar signs (ataxic ("drunken") gait or decreased coordination during rapid alternating hand or foot movements * score of \>1 on question 1b and \>0 on question 1c on NIH Stroke Scale * inability to communicate with investigators * musculoskeletal conditions or pain that limit walking * neglect/hemianopia, or unexplained dizziness in last 6 months * neurologic conditions or diagnoses other than stroke * lack of sensation in lower limb affected by stroke * any medical diagnosis that would hinder the participant from completing the experimental trial * diabetes not controlled by medication or causing risk for participation in exercise programs * additional exclusion criteria due to contra-indications to TMS (measurement of corticospinal excitability) are: history of seizures, metal implants in the head or face, history of recurring or severe headaches/migraine, headache within the past 24 hours, presence of skull abnormalities or fractures, hemorrhagic stroke, history of dizziness, syncope, nausea, or loss of consciousness in the past 6 months