Clinical Research Directory

Follicular Fluid Exosome miRNA During Oocyte Maturation

Sponsor: Chinese University of Hong Kong

Summary

Folliculogenesis involves the recruitment of primordial follicles into a group of growing follicles in which eventually one follicle is selected, matured and ovulated. Complex endocrine and intra-ovarian paracrine interactions occur to create a changing intra-follicular hormonal milieu suitable for oocyte development. However, this oocyte developmental competence and to undergo fertilization and embryogenesis is impaired in aged women. Diminished ovarian function is generally attributed to decreased quantity and quality of oocytes and their surrounding granulosa cells during ovarian aging, although the underlying mechanisms remain unclear. The aim of the study is to investigate the miRNA in (follicular fluid) FF exosome in young and aged women and their relationship to egg maturation.

Official title: Investigation of Follicular Fluid Exosome miRNA in Young and Aged Women During Oocyte Maturation

Key Details

Conditions

Locations (1)