Clinical Research Directory

Inclusion Criteria: * Histology confirmed non-obstructive adenocarcinoma of stomach or esophago-gastric junction. * Clinical stage: Clinical Tumor-Node-Metastasis (cTNM:) stage III * Performance status: Eastern Cooperative Oncology Group (ECOG) ≤ 2 (normal to symptomatic but in bed less than half the day) * Clinically fit for systemic chemotherapy and gastric cancer surgery, i.e. adequate renal, hepatic, hematologic and pulmonary function. * Written informed consent Exclusion Criteria: * Clinically unfit for systemic chemotherapy and gastric cancer surgery, i.e. uncontrolled cardiac disease, or other clinically significant uncontrolled comorbidities, unable to undergo general anesthesia * Distant metastases (including retroperitoneal lymph node) * Locally advanced inoperable disease (Clinical assessment) * Relapse of gastric cancer * Malignant secondary disease * Prior chemo or radio therapy * Inclusion in another clinical trial * Known contraindications or hypersensitivity for planned chemotherapy