Clinical Research Directory

Inclusion Criteria: * Male or female aged 18 to 65, * Subject with stress (DASS-42 screening scale ≥14) and having been under stress for at least 1 month, * Subject free of any introduction of new treatment or diet at the time inclusion, * Subject free of any treatment in the 7 days prior to inclusion including no use of analgesic or anti-inflammatory drugs, * Cooperation and understanding sufficient to comply with the requirements of the study, * Acceptance to give written consent, * Affiliation with the French Social Security, * Registration or acceptance of registration in the national register of volunteers participating in Research. Exclusion Criteria: * Contraindications to the realization of MRI without injection such as claustrophobia proven, hearing aid, pacemaker wearers, wearing a brain clip, * Contraindication to Mg administration: hypersensitivity to Mg oxide, or to one of the excipients, * With magnesemia \> 1.07 mmol/l, * With moderate (or more severe) kidney failure with creatinine clearance \<60 ml/min, * Receiving a treatment or dietary supplement containing Mg, pre- or probiotics, or herbal extracts (e.g. anti-stress, anti-inflammatory, analgesic) at the time of inclusion, * Treated with antibiotics in the three months prior to inclusion, * Having a medical and/or surgical history judged by the investigator or his or her representative that are not compatible with the trial, * Evolutionary pathology at the time of the inclusion, * Excessive consumption of alcohol, tobacco (up to 10 cigarettes per day), coffee, tea or drink containing caffeine (equivalent to more than 4 cups per day) or substance abuse, * Subject who does not meet the selection criteria for their ability to discriminate against sensations resulting from nociceptive stimulation during psychometric tests, * Subject who does not meet the selection criteria for their ability to discriminate against colours projected during the fMRI exam, * Subject participating in another clinical trial, or in the exclusion period, or having received a total amount of compensation of more than 4,500 euros over the 12 months prior to the start of the trial, * Woman of childbearing age not using an effective contraceptive method, pregnant woman or breastfeeding.